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When More Data Isn't Always Better: Mastering Nanoparticle Prediction with DAMM-Diffusion
Introduction In the fight against cancer, Nanoparticles (NPs) represent a futuristic and highly promising weapon. These microscopic carriers can be designed to deliver drugs directly to tumor sites, leveraging the “leaky” blood vessels of tumors to accumulate exactly where they are needed—a phenomenon known as the Enhanced Permeability and Retention (EPR) effect. However, simply injecting nanoparticles isn’t enough. To maximize therapeutic outcomes, doctors need to know exactly how these particles will distribute within a tumor. Will they reach the core? Will they stay on the periphery? This distribution is heavily influenced by the Tumor Microenvironment (TME), specifically the layout of blood vessels and cell nuclei. ...
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